Bacterial antigens encourage white blood cells to release MIF in to the blood stream.[10] The circulating MIF binds to CD74 on other immune cells to result in an acute immune reaction. therefore, MIF is classified being an inflammatory cytokine.
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Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by constructions-centered virtual screening and in vitro bioassays
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The cellular amounts of CD74 as well as the serum and cellular levels of MIF are elevated in genitourinary cancers.